Differences in peripheral blood inflammatory cytokine levels between adolescent patients with unipolar and bipolar depression
10.3969/j.issn.1002-0152.2025.05.005
- VernacularTitle:青少年单、双相抑郁障碍患者外周血炎症细胞因子水平差异
- Author:
Hailing JIA
1
;
Yongtao YANG
;
Lijun CUI
Author Information
1. 河北省精神卫生中心,河北大学第六临床医学院睡眠医学科(保定 071000)
- Publication Type:Journal Article
- Keywords:
Adolescents;
Bipolar disorder;
Major depressive disorder;
Inflammation;
Cytokines;
Proinflamma-tory cytokines;
Antiinflammatory cytokines;
IL-13
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(5):286-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences in inflammatory cytokine levels between adolescent patients with unipolar and bipolar depressive disorders.Methods A total of 32 patients aged 15-24 years with major depressive disorder(unipolar group),53 patients with bipolar depressive episodes(bipolar group),and 25 healthy controls(control group)were enrolled.The 17-item Hamilton depression scale(HAMD-17),Hamilton anxiety scale(HAMA),and 32-item hypomania checklist(HCL-32)were used to assess the clinical symptoms of the patients.The levels of inflammatory cytokines in all samples were measured using the enzyme-linked immunosorbent assay(ELISA)method.Results Compared with the unipolar group,the bipolar group had an earlier age of onset,a longer total disease duration,a shorter current episode duration,lower HAMD scores,and higher HCL-32 scores,with significant differences(P<0.05).There were significant differences in the levels of interleukin-1β(IL-1β),IL-6,interferon-γ(INF-γ),tumor necrosis factor-α(TNF-α),tumor necrosis factor receptor 2(TNFR2),IL-4,IL-10,and IL-13 among the three groups of subjects(P<0.05).Pairwise comparison showed that compared with the control group,both unipolar and bipolar groups exhibited the significant elevations in pro-inflammatory cytokines IL-1β,IL-6,and TNF-α(all P<0.05)and remarkable reductions in the anti-inflammatory cytokines IL-4,IL-10,and IL-13(all P<0.05).The levels of INF-γ and TNFR2 were significantly higher in the bipolar group than in the control group(P<0.05).Compared with the unipolar group,the levels of INF-γ[43.25(29.27,53.63)pg/mL vs.62.76(39.27,89.16)pg/mL]and IL-13[16.92(14.74,24.02)pg/mL vs.22.29(17.35,36.52)pg/mL]were significantly increased in the bipolar group.Multivariate logistic regression analysis showed that IL-13(OR=1.078,95％CI:1.011-1.150,P=0.022)was independently associated with bipolar depressive disorder.Conclusion Adolescents with unipolar and bipolar depressive disorders exhibit changes in inflammatory cytokines,and the IL-13 and INF-γ are higher in bipolar depressive episodes than in major depressive disorder.Higher levels of IL-13 are associated with bipolar depressive disorder.
