Analysis of clinical features of " small tumors with large metastases" in solid lung cancer nodules
10.3760/cma.j.cn115807-20250105-00007
- VernacularTitle:"小肿瘤大转移"实性肺癌结节的临床特征分析
- Author:
Jinfeng CHEN
1
;
Weiyi LI
;
Min AO
;
Junhao MU
;
Li YANG
Author Information
1. 重庆医科大学第一附属医院呼吸与重症医学科，重庆 400016
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Solid pulmonary nodules;
T1 stage;
Clinical features;
Bone metastasis
- From:
Chinese Journal of Endocrine Surgery
2025;19(1):81-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Special clinical types of lung cancer nodules with " small tumors and big metastases" are seriously harmful to human health, but their clinical characteristics are rarely reported. The aim of this study is to analyse the clinical characteristics of these lung cancer nodules.Methods:From Jan. 2019 to Nov. 2024, patients with stage T1 solid lung cancer who were pathologically confirmed in the First Affiliated Hospital of Chongqing Medical University were prospectively collected and divided into lung cancer nodule with metastasis group (study group) and stage Ia lung cancer group (control group). The differences in clinical, imaging, pathological and molecular features between the two groups were compared, and the differences in the distribution of metastases in the study group and in patients with or without bone metastasis were analyzed.Results:A total of 827 patients with an average age of 62.65±11.01 years were included, including 425 in the study group and 402 in the control group. The proportion of males, number of smokers, nodule size and EGFR mutation rate in the study group were significantly higher than those in the control group (all P<0.05). Stage IV patients accounted for 63.76% in the study group, among which bone metastasis patients accounted for the highest proportion (51.66%), and alkaline phosphatase, calcium and phosphorus were significantly increased. Conclusions:Patients with smoking, male and solid lung cancer nodules are more likely to have " small tumor and large metastasis", and bone metastasis is the most common distant metastatic site. The increase of alkaline phosphatase, calcium and phosphorus is helpful for early identification of bone metastases.
