Salidroside alleviates progression of Parkinson's disease by modulating inflammatory responses
- VernacularTitle:红景天苷对帕金森小鼠炎性反应的影响
- Author:
Xiao-lin DONG
1
;
Gang WU
;
Yan-ping LI
;
Li-juan ZHANG
;
Fu-rong JIN
;
Rui LI
;
Hong-mei LI
;
Xiao-xiao ZHANG
;
Qing-yun LI
Author Information
- Publication Type:Journal Article
- Keywords: salidroside; Parkinson's disease; move-ment disorder; inflammatory response; autophagy; py-roptosis
- From: Chinese Pharmacological Bulletin 2025;41(7):1340-1345
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the neuroprotective effects of salidroside on Parkinson's disease(PD)through modulation of inflammatory responses and the underly-ing mechanisms.Methods Mice were divided into five groups:healthy control group,1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)disease group,low-dose Rhodioloside intervention group,medium-dose salidroside intervention group,and high-dose salidro-side intervention group.MPTP-induced PD mouse model was established,and salidroside intervention was administered.Behavioral changes,inflammatory cyto-kine levels,autophagy-related protein expression,and neurons were observed through histological analysis and immunohistochemical staining.Results After MPTP treatment,mice exhibited significant behavioral chan-ges,increased pro-inflammatory cytokines,decreased anti-inflammatory cytokines,reduced autophagy-related proteins,and evident pyroptosis.Salidroside interven-tion alleviated these changes in a dose-dependent man-ner.Conclusions Salidroside exerts neuroprotective effects on PD by alleviating inflammatory responses and promoting autophagy,thereby protecting neurons.
