Effects of alcoholism on nonalcoholic fatty liver disease
10.12360/CPB202411024
- VernacularTitle:酒精摄入对非酒精性脂肪肝发病进程的影响及潜在机制研究进展
- Author:
Hao-qing ZHU
1
;
Yan-ling WU
1
;
Ji-xing NAN
1
;
Li-hua LIAN
1
Author Information
1. 延边大学药学院,吉林延吉 133002
- Publication Type:Journal Article
- Keywords:
nonalcoholic fatty liver disease;
alcohol;
dual effects of alcohol intake on fatty liver;
liver damage;
pathogene-sis;
research progress
- From:
Chinese Pharmacological Bulletin
2025;41(7):1227-1230
- CountryChina
- Language:Chinese
-
Abstract:
NAFLD is the most prevalent chronic liver disease,which has become a world public health issue and the incidence rate is also showing an increasing trend.A series of liver disea-ses,such as simple fatty liver disease,NASH,liver cirrhosis,liv-er failure and liver cancer,can be collectively referred to as NAFLD.Through the study of numerous factors that influence the production of NAFLD,it has been found that the main patho-logical mechanism is excessive synthesis of fat,which is difficult to be transported into the blood,causing massive lipid accumula-tion.Alcohol has a direct damaging effect on liver and will in-hibit the breakdown of liver fat,eventually forming AFLD.How-ever,it is still controversial whether alcohol has a synergistic effect on NAFLD onset.This article provides a review on the effect of alcohol intake on NAFLD and its potential mechanisms of action.
