Successful treatment of mixed pulmonary infection with Rhizopus micro-spores and Aspergillus using isaconazole combined with lobectomy:one case report
10.12138/j.issn.1671-9638.20257008
- VernacularTitle:艾沙康唑联合肺叶切除术成功治疗肺小孢根霉合并曲霉菌混合感染1例
- Author:
Yuanfang DUAN
1
;
Caiyun XU
;
Yinpeng PAN
;
Chunfang ZHANG
;
Jiafu SONG
Author Information
1. 连云港市第一人民医院呼吸与危重症医学科,江苏连云港 222002
- Publication Type:Journal Article
- Keywords:
Rhizopus microspores;
pulmonary aspergillosis;
isaconazole;
lobectomy
- From:
Chinese Journal of Infection Control
2025;24(6):859-863
- CountryChina
- Language:Chinese
-
Abstract:
This paper reports the clinical characteristics as well as diagnosis and treatment processes of a patient with mixed pulmonary infection of Rhizopus microspores and Aspergillus.The patient had history of type 2 diabe-tes mellitus,and was admitted to the hospital due to diabetes ketoacidosis complicated with pneumonia.Clinical manifestations included cough,expectoration,and fever.Imaging examination showed inflammatory lesions of bila-teral lungs(mainly in the right lung)associated with local consolidation.Bronchoalveolar lavage fluid(BALF)smears and galactomannan antigen test(GM test)were both negative.Nucleic acid sequences of Rhizopus micro-spores and Aspergillus were detected by metagenomic next-generation sequencing(mNGS)at the early stage,while complicated infection of Klebsiella pneumoniae and COVID-19 were also found.The final pathological diagnosis was pulmonary mucormycosis combined with invasive pulmonary aspergillosis.The patient achieved clinical curing through the combination of isaconazole antifungal treatment and lobectomy of the right middle-lower lobes.
