Research progress on molecular pathogenesis related to dental fluorosis
10.3760/cma.j.cn231583-20240826-00294
- VernacularTitle:氟斑牙发病相关分子机制的研究进展
- Author:
Yu SHEN
1
;
Zhouyan PAN
;
Xia LIU
;
Yuan TIAN
Author Information
1. 遵义医科大学口腔医学院，遵义 563000
- Publication Type:Journal Article
- Keywords:
Fluorosis, dental;
Pathogenesis;
Signal pathway
- From:
Chinese Journal of Endemiology
2025;44(5):426-430
- CountryChina
- Language:Chinese
-
Abstract:
Dental fluorosis is a chronic fluorosis manifestation characterized by tooth discoloration and structural abnormalities, resulting from excessive fluoride intake through respiratory and digestive systems during tooth development. This exposure inhibits ameloblast differentiation and disrupts enamel crystal formation and mineralization processes. While the exact pathogenesis remains unclear, this review systematically examines recent underlying mechanisms of dental fluorosis in the past five years, focusing on endoplasmic reticulum stress, Ca 2+ homeostasis imbalance, gene expression abnormalities, autophagy dysregulation, and microRNA-mediated regulatory pathways, in order to gain a deeper understanding of its pathogenesis at the molecular level and provide theoretical basis for prevention and treatment of dental fluorosis.
