Clinicopathological analysis of 15 cases of primary cardiac tumors in children
10.13315/j.cnki.cjcep.2025.06.011
- VernacularTitle:儿童原发性心脏肿瘤15例临床病理学分析
- Author:
Wenting WANG
1
;
Zhi LI
;
Lian CHEN
;
Bin ZHANG
;
Jing JIN
Author Information
1. 上海市儿童医院/上海交通大学医学院附属儿童医院病理科,上海 200333
- Publication Type:Journal Article
- Keywords:
cardiac neoplasms;
children;
primary;
syndrome
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(6):765-770
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinical and pathological characteristics of primary benign,borderline,and malignant cardiac tumors in children.Methods 15 cases of primary cardiac tumors in children were collected,and their clinical manifestations,pathological morphology,and immunophenotypes were analyzed.Relevant literature was also reviewed.Results The age of 15 patients ranged from 0.3 to 12 years old,with an average age of about 5 years and a median age of 2 years.9 cases were males and 6 cases were females.4 cases were found to have heart masses during physical examination,3 cases were treated for symptoms of cerebral infarction,1 case was treated for limb weak-ness,1 case was treated for systemic edema,1 case was treated for accelerated heartbeat,1 case was treated for cough,1 case was treated for pneumonia,1 case was treated for abdominal pain,1 case was treated for vomiting,and 1 case was treated for fever and shortness of breath.Echocardiography showed 8 cases occurring in the left heart system(6 in the left atrium and 2 in the left ventricle),4 cases occurring in the right heart system(2 in the right atrium and 2 in the right ventricle),2 cases occurring in the pericardium,and 1 case occurring in the interventricular septum.Ac-cording to pathological diagnosis,13 cases were benign tumors(8 cases of mucinous tumors,4 cases of rhabdomyo-mas,and 1 case of fibroma),1 case was a malignant tumor(embryonal rhabdomyosarcoma),and 1 case was a border-line tumor(NTRK rearranged spindle cell tumor).Conclusion Primary cardiac tumors in children are relatively rare,and borderline and malignant tumors are even rarer.The types of common tumors are different from those in a-dults,and they are prone to misdiagnosis due to non-specific clinical symptoms.For specific cardiac tumors,it is rec-ommended to conduct genetic testing when necessary based on clinical manifestations to further investigate the possibili-ty of related syndromes.
