The role of tryptophan cycling in the occurrence and development of ulcerative colitis and colitis-associated colon cancer

VernacularTitle:色氨酸循环在溃疡性结肠炎及结肠炎相关性结肠癌发生发展中的作用
Author: Lihao SHI ¹ ; Yue LIU ; Lili ZHANG ; Yao LU ; Guangxi ZHOU
Author Information

1. 济宁医学院附属医院消化内科，济宁　272029
Publication Type:Journal Article
Keywords: Tryptophan; Colitis, ulcerative; Colitis-associated neoplasms
From: Journal of Chinese Physician 2025;27(4):627-631
CountryChina
Language:Chinese
Abstract: Tryptophan is an essential amino acid in all animals. After being metabolized through three pathways in the body, it generates many bioactive metabolites, which affect the physiological processes of the body and provide a basis for potential therapeutic targets of diseases, especially the Kynurenine pathway. This article introduces the roles of the three metabolic pathways of tryptophan in the occurrence and development of ulcerative colitis and colitis-associated colon cancer, with particular attention to the role of the Kynurenine pathway in immune regulation and its potential contradictory effects on ulcerative colitis and colitis-associated colon cancer.