Role and Mechanisms of Mechanical Stress-Induced Oxidative Stress in Vascular Remodeling
10.16156/j.1004-7220.2025.03.036
- VernacularTitle:机械应力诱导的氧化应激在血管重建中的作用与机制
- Author:
Ziqi SHANG
1
;
Zhijie YAN
1
;
Yingxin QI
1
;
Kai HUANG
1
Author Information
1. 上海交通大学生命科学技术学院,力学生物学研究所,上海 200240
- Publication Type:Journal Article
- Keywords:
mechanical stress;
oxidative stress;
vascular remodeling;
vascular diseases;
hypertension;
mechanobiology
- From:
Journal of Medical Biomechanics
2025;40(3):760-767
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of vascular diseases is extremely high and mechanical stress plays an important role in vascular remodeling.Reactive oxygen species(ROS)at physiological levels modulate cell signaling while excessive ROS trigger oxidative stress and induce injury.The types of mechanical stresses in the vascular system and the sources of ROS are summarized.Besides,the roles and mechanisms of mechanical stress-induced oxidative stress in vascular diseases are discussed.This review will facilitate a deeper understanding of vascular activity and disease development at the molecular level,provide potential targets for treating vascular diseases.In addition,there are still research gaps on the mechanism of oxidative stress induced by mechanical stress in vascular diseases.Therefore,the potential research direction of mechanical stress-induced oxidative stress in the vascular system is also predicted,with the aim to promote the development of mechanobiology to a certain extent.
