The Efficacy Evaluation of Fuzheng Jiedu Formula in Preventing Postoperative Recurrence and Metastasis of Lymph Node Metastatic Colorectal Cancer:A Multicenter,Retrospective Cohort Study
10.3870/j.issn.1672-0741.24.12.029
- VernacularTitle:扶正解毒方预防淋巴结转移性结直肠癌术后复发转移的疗效评价:一项多中心、回顾性队列研究
- Author:
Qi SHI
1
;
Meilu DU
;
Siyu CHEN
Author Information
1. 上海中医药大学附属市中医医院肿瘤三科,上海 200071
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
lymph node metastasis;
Fuzheng Jiedu formula;
relapse-free survival
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(3):388-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role and differences of Fuzheng Jiedu formula in preventing postoperative recurrence and metastasis in patients with lymph node metastatic colorectal cancer.Methods Patients were categorized into two cohorts based on whether they received systematic traditional Chinese medicine(TCM)treatment or not.The primary endpoint was re-lapse-free survival(RFS),while the secondary endpoint was the hazard ratio(HR).Results A total of 407 patients were includ-ed in the study.After propensity score matching,no significant difference was observed in baseline characteristics between the groups(P＞0.05).The Fuzheng Jiedu formula significantly reduced the risk of recurrence and metastasis[HR:0.46,P＜0.05,Full Analysis Set(FAS)analysis],which was consistent with Per-Protocol Set(PPS)analysis.In the FAS analysis,for patients with＜4 involved lymph nodes(N1),the risk of recurrence and metastasis in the TCM group was 0.548 times that of the non-TCM group(95％CI:0.365-0.823).For patients with ≥4 involved lymph nodes(N2),the risk of recurrence and metastasis in the TCM group was 0.260 times that of the non-TCM group(95％CI:0.138-0.490).The findings from the PPS analysis were consistent.Conclusion The Fuzheng Jiedu formula can effectively reduce the risk of recurrence and metastasis after surgery for lymph node metastatic colorectal cancer,particularly benefiting patients in stage N2.
