Research progress of hemorrhagic transformation after reperfusion therapy for acute ischemic stroke
10.3760/cma.j.cn431274-20240419-00677
- VernacularTitle:急性缺血性卒中再灌注治疗后出血转化的研究进展
- Author:
Yiyi LIANG
1
;
Zhihong ZHAO
1
Author Information
1. 湖南省人民医院（湖南师范大学附属第一医院）神经内科，长沙 410005
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Reperfusion;
Hemorrhagic transformationn
- From:
Journal of Chinese Physician
2025;27(3):472-477
- CountryChina
- Language:Chinese
-
Abstract:
Reperfusion therapy is the most critical treatment for acute ischemic stroke. However, reperfusion treaty-related hemorrhagic transformation is a potential serious complication, which increases the disability rate and fatality rate of patients. The pathophysiological mechanism of symptomatic hemorrhage transformation involves core factors such as blood-brain barrier injury, inflammatory response, oxidative stress, etc. The main signaling pathways include Wnt/β-catenin, toll-like receptor(TLR)/toll-like interleukin 1 receptor(TRAF)/nuclear factor-κB(NF-κB), RhoA/ROCK and transforming growth factor β (TGF-β)-Smad3. They affect the integrity and stability of the blood-brain barrier through different pathways, thereby regulating the risk of bleeding transformation. This review focuses on the pathophysiological mechanism, biomarker related risk factors and imaging factors of hemorrhage transformation after reperfusion therapy in acute ischemic stroke.
