Research Progress of Neutrophil Extracellular Trapping Nets in Inflammatory Joint Diseases
10.3870/j.issn.1672-0741.24.12.024
- VernacularTitle:中性粒细胞胞外诱捕网在炎症性关节疾病中的研究进展
- Author:
Yiwei YUAN
1
;
Zifeng YE
;
Le ZHANG
Author Information
1. 湖南中医药大学研究生院,长沙 410208
- Publication Type:Journal Article
- Keywords:
neutrophil extracellular traps;
inflammatory joint disease;
pathogenesis;
research progress
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(3):428-432
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory joint diseases are a common type of chronic joint disorders including rheumatoid arthritis,ankylo-sing spondylitis and gouty arthritis,which usually lead to pain and even joint deformity.Its pathogenesis is complex and related to multiple factors.Neutrophils,as the first line of defense of the body,play a significant role in the early stage of pathogen inva-sion.Neutrophil extracellular traps(NETs)are released from activated neutrophils to trap and kill microorganisms,protecting the body from invasion.However,recent studies have shown that although NETs play a role in the body's defense,overly or ab-normally activated NETs play a driving role in various diseases,such as systemic lupus erythematosus,diabetes,tumors,etc.However,there are relatively few studies on the role of NETs in inflammatory joint diseases.This article sorts out the phys-iological characteristics,formation conditions of NETs,and their association with inflammatory joint diseases,with the aim of finding new targets for the effective treatment of inflammatory joint diseases.
