Role of Receptor Protein Tyrosine Phosphatases(RPTPs)in the Nervous System Development and Disease
10.13241/j.cnki.pmb.2025.12.020
- VernacularTitle:受体蛋白酪氨酸磷酸酶在神经系统发育和疾病中的作用
- Author:
Si-yan HE
1
;
Ji-hong GONG
1
;
Xiao-fei YANG
1
Author Information
1. 中南民族大学生物医学工程学院认知科学重点实验室湖北省医学信息分析与肿瘤诊疗重点实验室膜离子通道与药物研发实验室 湖北武汉 430074
- Publication Type:Journal Article
- Keywords:
Receptor Protein Tyrosine Phosphatases;
Neuropsychiatric Disorders;
Synapse Formation;
Neurite Development
- From:
Progress in Modern Biomedicine
2025;25(12):2064-2074
- CountryChina
- Language:Chinese
-
Abstract:
Receptor Protein Tyrosine Phosphatases(RPTPs)are a class of membrane proteins that play a crucial role in cellular signal transduction,primarily responsible for regulating the level of protein tyrosine phosphorylation within cells.They participate in various biological processes such as cell proliferation,differentiation,migration,and apoptosis.As a key group of signal transduction regulators,RPTPs are involved in multiple signaling pathways in the nervous system,such as regulating neuronal development,dendritic and axonal growth,and synapse formation.These functions are crucial for the normal development and maintenance of the nervous system.Studies have shown that RPTPs are involved in the occurrence and development of various neuropsychiatric disorders,such as bipolar disorder,autism,schizophrenia,and restless leg syndrome,and are considered potential therapeutic targets.Several studies are exploring how to regulate their expression and function.Here we review the studies of RPTPs in the nervous system,including their roles in axon guidance,synapse formation,and neuropsychiatric disorders,which helps to understand the functions of RPTPs and provides a basis for finding new therapeutic targets for neuropsychiatric diseases.
