Correlation analysis of neutrophil/lymphocyte ratio and urinary albumin/creatinine ratio in diabetic nephropathy patients
10.3760/cma.j.cn431274-20240229-00348
- VernacularTitle:糖尿病肾病患者中性粒细胞/淋巴细胞比值与尿白蛋白/肌酐比值的相关性分析
- Author:
Lei LI
1
;
Xiuli HE
1
;
Yao YAO
1
Author Information
1. 淮南阳光新康医院内分泌科，淮南 232007
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Neutrophil;
Lymphocytes;
Albumins;
Creatinine
- From:
Journal of Chinese Physician
2025;27(2):206-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between neutrophil-to-lymphocyte (NLR) and urinary albumin-to-creatinine ratio (UACR) in patients with diabetic nephropathies (DN).Methods:A total of 200 patients with DN admitted to the Endocrinology Department of the Sunshine Xinkang Hospital of Huainan from January 2020 to June 2022 were included, and 167 patients with simple type 2 diabetes mellitus (T2DM) admitted during the same period were randomly included. Clinical baseline data of all patients were collected, and indexes such as NLR and UACR were detected in the two groups. Pearson correlation analysis was used to evaluate the correlation between the above indicators and clinical indicators of diabetic nephropathy, and multi-factor logistic regression analysis was used to evaluate the influencing factors of the occurrence of DN. Receiver operating characteristic (ROC) curve was used to analyze the clinical value of DN recognition.Results:The diabetes course, glycated hemoglobin A 1c (HbA 1c), creatinine (Cr), blood urea nitrogen (BUN), NLR, interleukin (IL)-6, high-sensitivity C-reactive protein (hs-CRP) and UACR levels in DN group were significantly higher than those in the T2DM group, but the estimated glomerular filtration rate (eGFR) in the DN group was significantly lower than that in the T2DM group (all P<0.05). Pearson correlation analysis showed that UACR was positively correlated with NLR ( r=0.595, P<0.001), HbA 1c ( r=0.642, P<0.01), Cr ( r=0.469, P=0.014) and IL-6 ( r=0.395, P=0.037). It was negatively correlated with eGFR ( r=-0.483, P<0.01). Multivariate logistic regression analysis showed that the duration of diabetes mellitus, HbA 1c, UACR and NLR were independent risk factors for the development of DN in T2DM patients ( OR=2.87, 1.14, 1.44, 2.01, all P<0.05). ROC curve showed that UACR had the highest clinical value in the diagnosis of DN, and its area under the curve (AUC) (95% CI) was 0.90 (0.86-0.94), which was significantly higher than NLR and HbA 1c (all P< 0.05). The value of NLR in the diagnosis of DN was higher than that of HbA 1c, with AUC of 0.83 (0.78-0.88) and 0.76 (0.70-0.82), respectively ( P<0.05). Conclusions:The NLR and UACR in peripheral blood of patients with DN are significantly increased, and these indicators are correlated with renal function in patients with DN, and are potential markers for the diagnosis of DN.
