MRI Characteristics and Differential Diagnosis of Benign and Malignant Ductal Lesions with Microcalcifications Detected by Mammography
10.13241/j.cnki.pmb.2025.12.016
- VernacularTitle:钼靶显示微钙化的导管内病变MRI表现特征及良恶性鉴别诊断研究
- Author:
Lin CHEN
1
;
Chun-hong ZHENG
;
Feng JIANG
;
Xiang-xiu ZHANG
;
An-wen CAI
Author Information
1. 福建中医药大学附属第二人民医院 健康管理中心(治未病)放射科 福建 福州 350001
- Publication Type:Journal Article
- Keywords:
Microcalcifications;
Ductal lesions;
Magnetic resonance imaging;
Mammography;
Benign and malignant differentiation;
Apparent diffusion coefficient
- From:
Progress in Modern Biomedicine
2025;25(12):2034-2041
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the MRI characteristics of ductal lesions with microcalcifications detected by mammography,and to evaluate the value of MRI in the differential diagnosis of benign and malignant ductal lesions.Methods:The clinical data of 112 patients with pathologically confirmed ductal lesions with microcalcifications detected by mammography in our hospital from January 2022 to June 2024 were retrospectively analyzed.All patients underwent mammography and MRI examinations.MRI morphological features,dynamic enhancement characteristics,diffusion-weighted imaging(DWI)findings,and apparent diffusion coefficient(ADC)values were analyzed and compared with pathological results.The diagnostic performance of various MRI features was analyzed using ROC curves.Results:Among the 112 patients,there were 47 benign lesions and 65 malignant lesions.Malignant lesions were more likely to present with irregular morphology,heterogeneous T2 signal,lobulation,and spiculation(P＜0.05),while benign lesions were more likely to present with round or oval shapes and homogeneous T2 signal(P＜0.05).Malignant lesions predominantly showed fast rise-fast washout(Washout type)enhancement curves(58.5％),while benign lesions predominantly showed persistent rise(Progressive type)enhancement curves(55.3％).The ADC values of malignant lesions(0.92±0.21× 10-3 mm2/s)were significantly lower than those of benign lesions(1.45±0.28× 10-3 mm2/s)(P＜0.001).The combined application of morphological features,dynamic enhancement curves,and ADC values had the highest diagnostic performance,with a sensitivity of 92.3％,specificity of 89.4％,and accuracy of 91.1％.Conclusion:Multi-parameter MRI can comprehensively evaluate ductal lesions with microcalcifications detected by mammography.The combined application of morphological features,dynamic enhancement curve types,and ADC values can effectively improve the accuracy of differential diagnosis between benign and malignant lesions,providing important basis for clinical treatment decisions.
