Relationship between Serum GATA Binding Protein-3,Eosinophilic Cationic Protein and Pulmonary Function Index and Prediction of Poor Prognosis in Children with Obliterated Bronchiolitis
10.13241/j.cnki.pmb.2025.12.009
- VernacularTitle:血清GATA结合蛋白-3、嗜酸性阳离子蛋白与闭塞性细支气管炎患儿肺功能指标的关系及对不良预后的预测研究
- Author:
Jin-hai LIN
1
;
Yan WANG
1
;
Fang WU
1
;
Xin-ling WANG
1
;
Zong-zheng LIN
1
Author Information
1. 厦门医学院附属第二医院儿科 福建厦门 361021
- Publication Type:Journal Article
- Keywords:
Obliterated bronchiolitis;
GATA binding protein-3;
Eosinophilic cationic protein;
Pulmonary function index;
Poor prognosis
- From:
Progress in Modern Biomedicine
2025;25(12):1983-1988,2016
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between serum GATA binding protein-3(GATA3)and eosinophilic cationic protein(ECP)and lung function indexes in children with obliterated bronchiolitis and their predictive value for poor prognosis.Methods:96 children with bronchiolitis obliterans admitted to our hospital from January 2022 to July 2024 were divided into mild group(34 cases)and moderate to severe group(62 cases)according to their severity.Serum GATA3,ECP levels and lung function indexes were detected in the two groups,and Pearson correlation was used to analyze the correlation between serum GATA3,ECP levels and lung function indexes.According to the levels of serum GATA3 and ECP,they were divided into high GATA3 group and low GATA3 group,high ECP group and low ECP group.The incidence of adverse prognosis in different groups was compared.Area under ROC curve(AUC)was used to evaluate the predictive efficacy of serum GATA3 combined with ECP for poor prognosis.Results:The levels of serum GATA3 and ECP in moderate and severe group were higher than those in mild group(P＜0.05).By Pearson correlation analysis,serum GATA3 and ECP levels were negatively correlated with tidal volume(VT),peak-to-expiratory volume(VPEFNE)and peak-to-time ratio(TPTEF/TE)in children with bronchiolitis obliterans(P＜0.05).The incidence of adverse prognosis in the high GATA3 group was higher than that in the low GATA3 group,and the incidence of adverse prognosis in the high ECP group was higher than that in the low ECP group(P＜0.05).ROC curve analysis showed that serum GATA3 combined with ECP had a sensitivity of 90.45％,specificity of 52.37％and AUC of 0.893 in predicting adverse prognosis of children with bronchiolitis obliterans.Conclusion:Serum GATA3 and ECP are closely related to pulmonary function indexes in children with bronchiolitis obliterans.The combined effect of GATA3 and ECP is better in predicting poor prognosis,and it has a certain suggestive role in evaluating the disease.
