Study on Correlation between TCM Syndrome Types and RNF180/Septin9 Gene Methylation in Chronic Gastritis
10.19879/j.cnki.1005-5304.202412051
- VernacularTitle:慢性胃炎中医证型与RNF180/Septin9基因甲基化相关性研究
- Author:
Xin BAI
1
;
Xiaofei GUO
1
;
Aili XU
1
;
Yimeng ZHANG
1
;
Yuan WANG
1
;
Jianqi BAI
1
;
Ping ZHANG
1
Author Information
1. 中国中医科学院望京医院,北京 100102
- Publication Type:Journal Article
- Keywords:
chronic gastritis;
TCM syndrome type;
RNF180/Septin9 gene methylation;
correlation
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(7):148-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between different TCM syndrome types and RNF180/Septin9 gene methylation in patients with chronic gastritis.Methods Hospitalized cases diagnosed with chronic gastritis from March 2022 to July 2024 were retrieved through the information system of Wangjing Hospital,China Academy of Medical Sciences.Information such as general conditions,pathological findings and RNF180/Septin9 gene methylation detection results were collected.A total of 441 patients with chronic gastritis were finally collected according to the attrition criteria,and were divided into 5 types:liver-stomach disharmony syndrome,spleen-stomach damp-heat syndrome,spleen-stomach weakness syndrome,stomach-collateral stasis syndrome and stomach-yin deficiency syndrome.SPSS 25.0 was used to analyze the correlation between TCM syndrome types of chronic gastritis and methylation of RNF180/Septin9 gene.Results The majority of 441 patients with chronic gastritis were spleen-stomach damp-heat syndrome.The results of statistical analysis showed that there were differences in gender,smoking and drinking history and age distribution among different TCM syndrome types(P<0.05).The positive rate of RNF180/Septin9 gene methylation in stomach-collateral stasis syndrome was significantly higher than that in other syndrome types(P<0.01).Correlation analysis further showed that spleen-stomach damp-heat syndrome and stomach-collateral stasis syndrome were positively correlated with RNF180/Septin9 gene methylation(P<0.05),and the correlation of stomach-collateral stasis syndrome was particularly significant(P<0.01).Conclusion Spleen-stomach damp-heat syndrome and stomach-collateral stasis syndrome are positively correlated with RNF180/Septin9 gene methylation in patients with chronic gastritis.Pathological products such as blood stasis and damp-pathogenic bacteria can increase the risk of"inflammatory-cancer"transformation,and its prognosis is worse than other syndrome types.Timely intervention and regular examination should be conducted to achieve early diagnosis and treatment.
