The application prospects of mesenchymal stem cell-derived exosomes in the treatment of temporoman-dibular joint osteoarthritis
10.3969/j.issn.1001-3733.2025.06.020
- VernacularTitle:间充质干细胞来源外泌体在颞下颌关节骨关节炎治疗中的应用前景
- Author:
Youzhen XIAO
1
;
Fuwei LIU
1
;
Zhiye LI
1
;
Jin SHI
1
;
Weiwei GUO
1
;
Yunpeng LI
1
Author Information
1. 710032 西安,口颌系统重建再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床研究中心,空军军医大学口腔医院口腔颌面外科
- Publication Type:Journal Article
- Keywords:
Temporomandibular joint;
Osteoarthritis;
Exosome;
Mesenchymal stem cell
- From:
Journal of Practical Stomatology
2025;41(6):841-847
- CountryChina
- Language:Chinese
-
Abstract:
Temporomandibular joint osteoarthritis(TMJOA)is a chronic degenerative disorder.Although current clinical interven-tions can effectively mitigate disease progression,they remain limited in fully reversing formed pathological structural alterations.Mesenchymal stem cell-derived exosomes(MSC-Exos),which mimic the primary therapeutic functions of mesenchymal stem cells,exhibit advantages such as excellent biocompatibility,low immunogenicity,and absence of cytotoxicity.In TMJOA,MSC-Exos exert therapeutic effects by modulating chondrocytes,immune cells,and the cartilage matrix.However,the clinical application of MSC-Exos still faces certain limitations.Enhancing their therapeutic efficacy has become a central research focus in this field.This review summarizes existing therapeutic strategies for TMJOA and explores the potential applications of MSC-Exos in TMJOA management,aiming to provide insights for future research.
