Clinical distribution and trend of drug resistance of Klebsiella pneumoniae isolates from a three-A hospital of Suzhou from 2019 to 2023
10.11816/cn.ni.2025-241638
- VernacularTitle:2019-2023年苏州某三甲医院肺炎克雷伯菌临床菌株分布及耐药性变迁
- Author:
Jingjing GAO
1
;
Ning SU
1
;
Lu YUAN
1
;
Lan HUANG
1
;
Li-jun XU
1
;
Wei-dong XU
1
;
Ya-nan WANG
1
Author Information
1. 南京医科大学附属苏州医院 苏州市立医院检验医学中心,江苏苏州 215002;苏州市智慧+重大疾病生物标志物研究与转化重点实验室,江苏苏州 215104
- Publication Type:Journal Article
- Keywords:
Klebsiella pneumoniae;
Carbapenem-resistant Klebsiella pneumoniae;
Infection;
Change of drug re-sistance;
Management of antibiotics
- From:
Chinese Journal of Nosocomiology
2025;35(13):2007-2012
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the clinical distribution and dynamic change of drug resistance of K.pneu-moniae and carbapenem-resistant Klebsiella pneumoniae(CRKP)isolated from a three-A hospital of Suzhou so as to provide scientific bases for prevention and control of hospital-associated infections and reasonable application of antibiotics.METHODS The K.pneumoniae and CRKP strains that were isolated from the submitted specimens were collected from the patients who treated in the Affiliated Suzhou Hospital of Nanjing Medical University from 2019 to 2023.The clinical characteristics of the patients with infection and the trend of drug resistance were statis-tically analyzed.RESULTS Totally 5631 strains of K.pneumoniae were isolated,1205(21.40％)of which were CRKP,and the isolation rate of CRKP showed an upward trend in the five years(x2=236.352,P＜0.001).Among the K.pneumoniae isolates,51.59％were isolated from sputum,13.51％from urine;19.43％were isolated from intensive care unit(ICU),7.64％from emergency department,and 7.19％from respiratory department.There were significant differences in gender,age and season between the patients detected with CRKP and the patients detected with non-CRKP(P＜0.05).The drug resistance rates of the K.pneumoniae strains to cephalosporins,quinolones and carbapenems con-tinuously increased from 2019 to 2023(P＜0.001),the drug resistance rate to imipenem increased from 11.69％to 34.24％,meropenem from 10.92％to 34.24％.CONCLUSIONS The K.pneumoniae isolates show severe drug re-sistance from 2019 to 2023,and the isolation rate of CRKP strains rises increasingly.It is necessary for the hospi-tal to focus on the continuous monitoring of key populations and departments and optimize the management of an-tibiotics and infection control strategies so as to provide guidance for reasonable clinical use of antibiotics,effective control of transmission of drug-resistant strains and cope with the increasingly severe drug resistance.
