Peripheral blood TGF-β1 gene polymorphisms and change of related markers in cardiac surgery children with postoperative catheter-related bloodstream infections
10.11816/cn.ni.2025-241023
- VernacularTitle:儿童心脏手术后导管相关血流感染外周血TGF-β1基因多态性及相关指标变化
- Author:
Jie JIANG
1
;
Xiang ZHANG
1
;
Fangfang LI
1
;
Meng DENG
1
;
Bo HUANG
1
;
Yingbo ZOU
1
Author Information
1. 遵义市第一人民医院(遵义医科大学第三附属医院)儿童重症医学科,贵州 遵义 563000
- Publication Type:Journal Article
- Keywords:
Child;
Cardiac surgery;
Catheter-related bloodstream infection;
Pathogen;
Transforming growth factorβ1;
High-sensitivity C-reactive protein;
Smad homolog 2;
Smad homolog 3;
Central venous catheter
- From:
Chinese Journal of Nosocomiology
2025;35(13):1978-1983
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the distribution of pathogens isolated from the cardiac surgery children with postoperative catheter-related bloodstream infection(CRBSI)and observe the transforming growth factor β1(TGF-β1)gene polymorphisms and the change of high-sensitivity C-reactive protein(hs-CRP),Smad homologue 2 and Smad 3 levels.METHODS A total of 88 children who received peripherally inserted central catheter(PICC)puncture after cardiac surgery and were complicated with postoperative CRBSI in the First People's Hospital of Zunyi from Aug.2019 to Oct.2023 were assigned as the infection group.Meanwhile,110 children who were trea-ted with PICC and did not have postoperative CRBSI were randomly chosen as the non-infection group.The base-line data,TGF-β1 gene polymorphisms and the levels of hs-CRP,Smad 2 and Smad 3 were compared between the two groups.The distribution of the pathogens isolated from the infection group was observed.The values of hs-CRP,Smad 2 and Smad 3 in diagnosis of the postoperative CRBSI in the cardiac surgery children were analyzed by receiver operating characteristic(ROC)curves.RESULTS The proportions of patients with intravenous cathe-ter indwelling no less than 10 days,length of intensive care unit(ICU)stay no less than 5 days,the frequencies of CC genotypes and C allele at TGF-β1+869C/T locus were higher in the infection group than those in the non-infection group(P＜0.05).Acinetobacter baumannii was the predominant species of pathogen isolated from the infection group,accounting for 24.20％.The levels of serum hs-CRP,Smad 2 and Smad 3 of the infection group were(24.65±7.65)mg/L,(13.54±2.45)pg/ml and(13.65±2.65)pg/ml,respectively,higher than those of the non-infection group(all P＜0.001).The area under the curve(AUC)of the joint detection of hs-CRP,Smad 2 and Smad 3 was highest in diagnosis of the postoperative CRBSI in the cardiac surgery children(P＜0.05).CONCLUSIONS A.baumannii is dominant among the pathogens isolated from the cardiac surgery children with postoperative CRBSI.The postoperative CRBSI may be associated with the intravenous catheter in-dwelling time and length of ICU stay.The C allele at TGF-β1+869C/T locus may be the susceptibility gene for the postoperative CRBSI.The joint detection of hs-CRP,Smad 2 and Smad 3 has the highest value in diagnosis of the postoperative CRBSI.
