Research progress on the inhibition of cardiac remodeling by vericiguat
10.12092/j.issn.1009-2501.2025.06.016
- VernacularTitle:维立西呱抑制心脏重构的研究进展
- Author:
Ding DING
1
;
Shengnan WU
1
;
Ancai WANG
1
;
Deguo WANG
1
Author Information
1. 皖南医学院第一附属医院(弋矶山医院)老年医学科,芜湖 241001,安徽
- Publication Type:Journal Article
- Keywords:
heart failure;
vericiguat;
cardiac re-modeling;
research progress
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(6):858-863
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure(HF)has become a major global medical burden.Despite the existence of several drugs for the treatment of HF,the progno-sis is still not optimistic,which motivates us to seek new treatments for this disease.Vericiguat,a novel soluble guanylate cyclase(sGC)stimulator,has been approved for use in patients with heart fail-ure.Cardiac remodeling is the important patho-physiological basis of cardiovascular disease occur-rence and development,and closely related to the prognosis of patients.Accumulating evidence sug-gests that vericiguat inhibits cardiac remodeling,but the molecular mechanism remains unclear.Therefore,an in-depth understanding of the molec-ular mechanism of action of vericiguat will be im-portant for future studies of this drug as a poten-tial therapy for slowing the severity of heart fail-ure.This article reviews the mechanism and re-search status of the inhibitory effect of Vericiguat on cardiac remodeling.
