Advances in pyroptosis in sepsis-associated acute kidney injury
10.11816/cn.ni.2025-241806
- VernacularTitle:脓毒症相关急性肾损伤细胞焦亡的研究进展
- Author:
Wenyu WU
1
;
Xin JIAO
;
Shaofeng ZHAN
;
Wanning LAN
;
Jingyu NIAN
;
Jingnan LIN
;
Kai WANG
;
Lin WANG
;
Ruifeng ZENG
;
Rui CHEN
;
Jun LI
Author Information
1. 广州中医药大学第一临床医学院,广东 广州 510405;广州中医药大学第一附属医院,广东 广州 510405;广东省中医临床研究院,广东 广州 510405
- Publication Type:Journal Article
- Keywords:
Sepsis;
Acute kidney injury;
Sepsis-associated acute kidney injury;
Pyroptosis;
Inflammasome;
Signa-ling pathway
- From:
Chinese Journal of Nosocomiology
2025;35(11):1743-1748
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a systemic inflammatory response triggered by infection and often leads to acute kidney injury(AKI).The pathogenesis of sepsis-associated AKI is complex,involving multiple factors such as renal ischemia,inflammation and oxidative stress.In recent years,pyroptosis,a pro-inflammatory form of programmed cell death,has gradually attracted the attention of researchers.Pyroptosis is activated by inflammasomes(e.g.,the NOD-like receptor pyrin domain-related protein 3 inflammasome,NLRP3 inflammasome),accompanied by Gas-dermin D(GSDMD)-mediated formation of cell membrane pores and release of cellular contents,which leads to exacerbation of local and systemic inflammatory responses.The mechanism of pyroptosis in sepsis-associated AKI has not been fully elucidated,but AKI is directly involved in the process of renal functional impairment by indu-cing the death of renal tubular epithelial cells and exacerbating the local inflammatory response.Blockade of key molecules in the pyroptosis pathway,such as GSDMD or NLRP3 inflammasome,can significantly alleviate renal injury,suggesting that the pyroptosis pathway may be a potential therapeutic target for sepsis-associated AKI.This review summarizes the recent research progress on pyroptosis in sepsis-associated AKI,and discuss its cen-tral role in the pathogenesis,particularly focusing on the inflammasome and GSDMD pathways.Additionally,this paper analyzes the potential of focal death inhibition as a therapeutic strategy and proposes future research direc-tions with the expectation of providing references for the treatment of sepsis-related AKI.
