Targeting the cGAS-STING pathway for the treatment of ischemic stroke
10.12092/j.issn.1009-2501.2025.05.013
- VernacularTitle:靶向cGAS-STING通路与缺血性脑卒中治疗研究进展
- Author:
Qingfang QIAN
1
;
Wenjing LI
1
;
Qiang LI
1
Author Information
1. 赤峰学院附属医院神经内科,赤峰 024005,内蒙古
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
cGAS;
STING;
neuro-protection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(5):690-694
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a devastating neuro-logical disease worldwide,with high global burden.The microglial activation-driven neuroinflammation plays a critical role in pathophysiology of ischemic stroke.After the ictus of brain ischemic attack,cy-tosolic double-stranded DNA(dsDNA)released by necrotic neuronal cells is a potential damage-asso-ciated molecular pattern(DAMP)to activate cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway.cGAS-STING sig-naling pathway has emerged as a key player in mi-croglial activation,sterile neuroinflammation,and cell death following ischemic stroke.Targeting this pathway holds promise for developing novel thera-peutics that effectively mitigate neuroinflamma-tion,prevent cell death,and enhance patient out-comes.In this review,we first outline the principal elements of the cGAS-STING signaling cascade,then discusses the pivotal role of the cGAS-STING pathway in ischemic stroke.Then,we outline selec-tive small-molecules modulators that function as cGAS-STING inhibitors and summarize their mecha-nisms to treat Ischemic stroke.Finally,we discuss key limitations of the current therapeutic paradigm and generate possible strategies to overcome them.
