Distribution and drug resistance of pathogens isolated from renal transplantation patients with postoperative nosocomial infections
10.11816/cn.ni.2025-241186
- VernacularTitle:肾移植术后患者医院感染病原菌及其耐药性
- Author:
Zhina YANG
1
;
Zhuo WANG
;
Yingnan CHEN
;
Chang LIU
;
Xuefang BEN
;
Minmin PENG
Author Information
1. 联勤保障部队北戴河康复疗养中心,河北秦皇岛 066000
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Postoperative infection;
Pathogenic bacterium;
Antibacterial drug;
Drug resistance
- From:
Chinese Journal of Nosocomiology
2025;35(12):1814-1817
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the distribution and drug resistance of pathogenic bacteria in hospital-associat-ed infections for patients after renal transplantation,and to provide a reference for the rational selection of antibac-terial drugs for anti-infective treatment in such patients.METHODS Clinical data were collected from 89 hospital-ized patients who underwent renal transplantation and developed hospital-associated infection at Beidaihe Rehabili-tation and Recuperation Center(formerly known as 281 Hospital)from 2017 to 2021.The pathogenic bacteria de-tected in different types of hospital-associated infections and the drug resistance of the main pathogenic bacteria were analyzed.RESULTS A total of 89 pathogenic bacterial strains were isolated from the 89 patients with hospi-tal-associated infection,including 74 gram-negative bacterial strains(83.15％)and 15 gram-positive bacterial strains(16.85％).The predominant pathogenic bacterial strains were Klebsiella pneumoniae,Escherichia coli and Pseudomonas aeruginosa.Respiratory tract infection was the most common.E.coli showed severe drug re-sistance,with high drug resistance rates to various antibacterial drugs(complete drug resistance to piperacillin and ampicillin).K.pneumoniae was generally drug resistant to ampicillin.Enterobacter cloacae showed high sensitivi-ty to carbapenems,amikacin and enzyme inhibitor combinations.P.aeruginosa had low drug resistance rates to imipenem and meropenem.Staphylococcus aureus was completely drug resistant to antibacterial drugs such as penicillin,erythromycin and gentamicin,and no drug-resistant strains to vancomycin and linezolid were found.CONCLUSIONS The gram-negative bacteria are dominant among the bacteria isolated from the renal trans-planted patients with postoperative hospital-associated infections,with a high detection rate of E.coli and a severe drug resistance situation.Therefore,it is necessary to strengthen the monitoring of drug resistance in renal trans-plant recipients and make rational choices of antibacterial drugs.
