Levels of PCT,NLR,SAA and PLR of newborns with bloodstream infection and their values in early diagnosis
10.11816/cn.ni.2025-241881
- VernacularTitle:血流感染新生儿PCT、NLR、SAA和PLR水平及其早期诊断价值
- Author:
Weiwei XIE
1
;
Jing LUO
1
;
Yanfen YING
1
;
Lizhen WANG
1
Author Information
1. 浙江省台州医院新生儿科,浙江台州 317000
- Publication Type:Journal Article
- Keywords:
Pathogenic bacterium;
Bloodstream infection;
Procalcitonin;
Platelet-to-lymphocyte rate;
Neutrophil-to-lymphocyte ratio;
White blood cell count;
Serum amyloid A
- From:
Chinese Journal of Nosocomiology
2025;35(12):1841-1845
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the levels of procalcitonin(PCT),platelet-to-lymphocyte ratio(PLR),neu-trophil-to-lymphocyte ratio(NLR),white blood cell count(WBC)and serum amyloid A(SAA)in newborns with bloodstream infection,and their diagnostic value for early diagnosis of bloodstream infection in newborns.METHODS A total of 100 neonates with positive blood culture results from Jan.2021 to Jan.2024 at Taizhou Hos-pital of Zhejiang Province were selected.These cases were divided into three groups based on the type of pathogen:74 cases in the gram-negative bacterial group,19 cases in the gram-positive bacterial group,and 7 cases in the fungal group.Additionally,100 neonates with negative blood culture results during the same period were selected as the control group.By comparing the levels of PCT,PLR,NLR,WBC and SAA in the blood of newborns infec-ted with different pathogens,the diagnostic value of various indicators on the receiver operating characteristic(ROC)curve for diagnosis of bloodstream infection in newborns was evaluated.RESULTS Among 100 newborns with positive blood cultures,74 strains of gram-negative bacteria,19 strains of gram-positive bacteria,and 7 strains of fungi were identified.The levels of PCT,PLR,NLR,WBC and SAA in the gram-positive,gram-negative and fungal groups were all higher than those in the control group(P＜0.05).The ROC curve re-sults showed that the diagnostic efficacy of the combination of PCT,PLR,NLR,WBC and SAA for gram-nega-tive and gram-positive bloodstream infections was superior to that of each individual indicator(P＜0.05),with ar-ea under the curve(AUC)of 0.982 and 0.969,respectively.CONCLUSION PCT,PLR,NLR,WBC and SAA can serve as effective biomarkers for the early diagnosis of bloodstream infection in newborns,aiding in the rapid and accurate identification of the type of infection.
