Effect of celecoxib preemptive analgesia on pain during and after treatment of mandibular posterior pulpitis
10.13591/j.cnki.kqyx.2025.05.009
- VernacularTitle:塞来昔布超前镇痛对下颌后牙牙髓炎治疗术中和术后疼痛的影响
- Author:
Guangming WANG
1
;
Guangdong ZHANG
Author Information
1. 南京医科大学附属口腔医院综合诊疗科,江苏南京(210029);口腔疾病研究及防治国家级重点实验室培育点,江苏南京(210029);江苏省口腔转化医学工程研究中心,江苏南京(210029);联勤保障部队第九○四医院口腔科,江苏无锡(214000)
- Publication Type:Journal Article
- Keywords:
celecoxib;
preemptive analgesia;
irreversible pulpitis;
inferior alveolar nerve block anesthesia;
root canal therapy
- From:
STOMATOLOGY
2025;45(5):371-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and safety of celecoxib preemptive analgesia on pain during root canal treatment of man-dibular posterior pulpitis.Methods Patients(n=120)with irreversible pulpitis of mandibular posterior teeth who underwent root canal treatment were randomly divided into group A as control group,group B as ibuprofen group and group C as celecoxib group.Standard o-ral doses of placebo,300 mg ibuprofen,and 200 mg celecoxib were respectively given 0.5 hours before surgery.During the operation,2％lidocaine was used for inferior alveolar nerve block anesthesia.Pulp opening,pulp extraction,root canal preparation,root canal calcium hydroxide disinfection and drug sealing were completed.The degree of pain before,during,and after treatment was evaluated using digital rating scale(NRS)0-10,and the onset,duration,and adverse effects of anesthesia were recorded.Results All cases had different degree of pain.However,the NRS score in celeoxib group was lower than that in ibuprofen group and control group(P＜0.05).There was no significant difference in NRS score between ibuprofen group and control group(P＞0.05),but postoperative score of ibuprofen group was lower than control group(P＜0.05).There was no significant difference in the duration of anesthesia among the three groups(P＞0.05).The onset time of anesthesia in celecoxib group was shorter than that in ibuprofen group and control group(P＜0.05).The onset time of anesthesia in ibuprofen group was shorter than that in control group(P＜0.05).There was no significant differ-ence in the incidence of anesthesia adverse reactions among the three groups(P＞0.05).Conclusion In the root canal treatment of mandibular posterior tooth irreversible pulpitis,oral celecoxib can effectively improve the effect of inferior alveolar nerve block anesthe-sia,shorten the onset time of anesthesia,reduce the intraoperative and postoperative pain of patients,and do not increase the incidence of adverse reactions,which is worthy of promotion and application.
