Potential target genes for spondylolisthesis:drugable genome analysis based on the European population-based biodatabase
- VernacularTitle:脊椎滑脱的潜在靶基因:基于欧洲人群生物数据库可成药基因组分析
- Author:
Qingfeng ZHANG
1
;
Chaoyi WANG
;
Jingyan YANG
;
Hanyu LI
;
Yuyang ZHAO
;
Huatao HAO
;
Dong YU
Author Information
- Publication Type:Journal Article
- Keywords: co-localization analysis; spondylolisthesis; Dsigbd database; drugable genes; whole genome-wide association studies
- From: Chinese Journal of Tissue Engineering Research 2026;30(6):1592-1601
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Spondylolisthesis is a common disease,and there is a lack of effective drugs to treat it.There is still a need to further define the pathogenesis and screen out more suitable therapeutic targets for spondylolisthesis.Mendelian randomization analysis can be used to explore the drugable genes associated with spondylolisthesis and provide valuable guidance for the development of more effective and targeted therapeutic drugs.OBJECTIVE:To explore potential therapeutic targets and effective drugs for spondylolisthesis by means of pharmaceutically available genome-wide Mendelian randomization analysis.METHODS:Using the Finnish database,eQTLGen consortium,drug signature database,drug-gene interaction database,protein-protein interaction database,organic small molecule biological activity database and protein structure database,which contains genome and health information of half a million Finns,data on druggable genes were subjected to two-sample Mendelian randomization analysis and co-localization analysis with data from genome-wide association studies of spondylolisthesis to identify genes highly associated with spondylolisthesis.In addition,GO and KEGG enrichment analysis,protein network construction,drug prediction and molecular docking were performed to provide valuable guidance for the development of more effective and targeted therapeutic agents.RESULTS AND CONCLUSION:In this study,we identified 34 potential drug target genes that were significantly associated with spondylolisthesis,particularly the gene APOBEC3G.This gene showed a significant association with spondylolisthesis outcomes through Mendelian analysis and co-localization analysis,suggesting that APOBEC3G may be a priority therapeutic target.As for other potential mechanisms and drugs,we still need to conduct more in-depth research to determine their roles.This study used a database from a European population,which can be used as a reference for the study of population genetics in China.
