Predictive value and clinical significance of serum miR-210 combined with HIF-1α for patients with acute cerebral infarction
10.3969/j.issn.1009-0126.2025.06.019
- VernacularTitle:微小RNA-210联合缺氧诱导因子对急性缺血性脑卒中患者预后的预测价值及临床意义
- Author:
Jiangjiang CHENG
1
;
Li MEI
;
Juan SUN
;
Xuejuan GUO
Author Information
1. 810000 西宁,青海大学附属医院神经内科
- Publication Type:Journal Article
- Keywords:
microRNAs;
brain infarction;
prognosis;
hypoxia inducible factor-1α
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(6):779-782
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes in serum microRNA-210(miR-210)and hypoxia-inducible factor(HIF-1α)levels before and after endovascular treatment in patients with acute ischemic stroke(AIS).Methods A total of 60 AIS patients admitted to the Neurology Depart-ment of Xining First People's Hospital from January 2023 to March 2024 were recruited,and based on the modified Rankin Scale(mRS)score in 3 months after onset,they were divided into a good prognosis group(41 cases,mRS score:0-2)and a poor prognosis group(19 cases,mRS score:3-6).Serum levels of miR-210 and HIF-1α were measured and compared before treatment,and at 3 and 7 d after treatment,and the levels were also compared between the good and poor prognosis groups before treatment and at 3 and 7 d after treatment.Spearman correlation analysis was used to evaluate the relationship between prognosis and serum miR-210 and HIF-1α levels in AIS patients.ROC curve analysis was performed to assess the predictive value of serum miR-210 and HIF-1α levels for prognosis.Results The serum levels of miR-210 and HIF-1α were significantly increased in the AIS patients at 3 and 7 d after treatment than those before(P＜0.05),with the miR-210 level at 7 d obviously higher than that at 3 d,and the HIF-1α level at 7 d notably lower than that at 3 d(P＜0.05).Spearman correlation analysis revealed a negative correlation between pre-treatment serum miR-210 level and prognosis(r=-0.271,P＜0.05),while a positive correla-tion between pre-treatment serum HIF-1α level and prognosis(r=0.398,P＜0.05).The expres-sion levels of miR-210 and HIF-1αwere significantly higher in the poor prognosis group than the good prognosis group(P＜0.01).ROC curve analysis indicated that the AUC value of miR-210 and HIF-1α in predicting prognosis was 0.818 and 0.815,with a specificity of 0.850 and 0.700,and a sensitivity of 0.800 and 0.800,respectively,and the AUC value of the two indicators combined together was 0.880,and the sensitivity was 0.900,significantly better than the single indicator(P＜0.01).Conclusion Post-treatment serum miR-210 and HIF-1α levels are closely related to mRS score in AIS patients.Their combined detection can improve the predictive accuracy for prognosis.
