Advances and application of neutrophil extracellular traps and activated platelets in lung cancer research
- VernacularTitle:中性粒细胞外诱捕网和活化血小板在肺癌研究中的进展与应用
- Author:
Daiyao YU
1
;
Ping SHI
;
Lan YANG
;
Zhishu LI
;
Yongping LU
Author Information
- Publication Type:Journal Article
- Keywords: lung cancer; activated platelet; neutrophil extracellular trap; biomarker; diagnosis
- From: Chinese Journal of Tissue Engineering Research 2026;30(1):229-237
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Neutrophil extracellular traps and activated platelets are involved in the invasion,metastasis,growth,and angiogenesis of lung cancer,and are closely related to the development and prognosis of lung cancer.OBJECTIVE:To review the mechanism of neutrophil extracellular traps and activated platelets in lung cancer and their application in diagnosis,prognosis,and treatment of lung cancer.METHODS:"Platelet activation,lung neoplasms,extracellular traps,treatment"for English search terms and"lung cancer,neutrophil-extracellular traps,platelet activation,P-selectin,treatment"for Chinese search terms were searched in PubMed and CNKI databases.After reading the title and abstract of the literature,according to the inclusion and exclusion criteria,63 articles with high relevance were finally included.RESULTS AND CONCLUSION:(1)Formation of neutrophil extracellular traps and platelet activation were induced by lung tumor.(2)Neutrophil extracellular traps and activated platelets jointly promote the proliferation,growth and metastasis of lung cancer.(3)Neutrophil extracellular traps can be used as a novel biomarker for the diagnosis,prognosis and progression of lung cancer.(4)Targeting neutrophil extracellular traps and activating platelets can be used as potential therapies for lung cancer.
