Association between red cell distribution width/albumin ratio and risk for non-valvular atrial fibrillation in hyperuricemia population
10.3969/j.issn.1009-0126.2025.06.008
- VernacularTitle:高尿酸血症人群中红细胞分布宽度与白蛋白比值和非瓣膜性心房颤动风险的关联研究
- Author:
Shuai ZHANG
1
;
Hao LIANG
;
Zhengyu BAO
;
Yong XIE
;
Ye ZHU
Author Information
1. 225001 扬州大学医学院
- Publication Type:Journal Article
- Keywords:
hyperuricacidemia;
atrial fibrillation;
erythrocytes;
serum albumin
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(6):727-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the ratio of red blood cell distribution width to albumin level(RAR)and the risk of non-valvular atrial fibrillation(NVAF)in patients with hyperuricemia.Methods A total of 8 277 patients with hyperuricemia who underwent physi-cal examinations at the Physical Examination Center of Northern Jiangsu People's Hospital from January 2021 to June 2024 were enrolled.From them,185 patients with AF were assigned into a case group,and 740 patients without AF were into a control group in a ratio of 1∶4 with propen-sity score matching(PSM).Logistic regression analysis,restricted cubic spline analysis,and sub-group analysis were employed to investigate the association between RAR and the risk of NVAF in hyperuricemic patients.Results The case group had significantly larger ratio of smoking,high-er levels of red blood cell distribution width,total bilirubin,hematocrit,and RAR index,but lower albumin,low-density lipoprotein cholesterol(LDL-C)and triglyceride(TG)levels,and smaller ra-tio of fatty liver than the control group(P＜0.01).Multivariate logistic regression analysis showed that the patients at Q2,Q3,and Q4 quartiles of RAR index have higher risk for AF than those at Q1 quartile(OR=2.843,OR=4.263,OR=7.801,P＜0.01).The effect of RAR index was significant when below the breakpoint of 2.85(OR=1.492,95％CI:1.151-1.993,P=0.004).Subgroup analysis indicated significant interactions between RAR index and age as well as smok-ing(P interaction＜0.05).The area under curve value of RAR index in predicting NVAF occurrence in male hyperuricemic patients was 0.679(95％CI:0.632-0.725).Conclusion In patients with hyperuricemia,a higher RAR index is associated with an increased risk of NVAF.RAR index has guiding significance for diagnosing male hyperuricemic patients complicated with AF.
