Change patterns of functional connectivity of basal forebrain subregions in Alzheimer disease patients
10.13929/j.issn.1003-3289.2025.05.002
- VernacularTitle:阿尔茨海默病患者基底前脑亚区功能连接变化模式
- Author:
Yujie HE
1
;
Shaozhen YAN
1
;
Zhigeng CHEN
1
;
Sheng BI
1
;
Hanxiao XUE
1
;
Bixiao CUI
1
;
Jie MA
1
;
Jie LU
1
Author Information
1. 首都医科大学宣武医院放射与核医学科,北京 100053;磁共振成像脑信息学北京市重点实验室,北京 100053;教育部神经变性病重点实验室,北京 100053
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
brain;
functional connectivity;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(5):701-705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change patterns of functional connectivity(FC)of basal forebrain subregions in Alzheimer disease(AD)patients.Methods Totally 42 AD patients(AD group)and 41 healthy controls(HC group)were retrospectively enrolled.Seed-based FC analysis was performed on basal forebrain subregions(Ch123 and Ch4)based on their resting-state functional MRI data and compared between groups.Results Compared with HC group,FC between left Ch4 and left hippocampus as well as left posterior cingulate gyrus significantly decreased,but between right Ch4 and right precentral gyrus,as well as right postcentral gyrus increased in AD group(GRF correction,voxel level P＜0.001,cluster level P＜0.05).Meanwhile,FC between left Ch123 and left superior temporal gyrus,left insula,between right Ch123 and left superior temporal gyrus,left temporal pole significantly increased,while between right Ch123 and right orbital superior frontal gyrus,right orbital inferior frontal gyrus significantly decreased in AD group(GRF correction,voxel level P＜0.001,cluster level P＜0.05).Conclusion FC changes of different basal forebrain subregions in AD patients were various.
