Research progress on pyroptosis in subarachnoid hemorrhage
10.3969/j.issn.1672-5921.2025.05.009
- VernacularTitle:细胞焦亡在蛛网膜下腔出血中的研究进展
- Author:
Bowen SUN
1
;
Shuai LAN
1
;
Xi'ao WANG
1
;
Shancai XU
1
;
Huaizhang SHI
1
Author Information
1. 150001 哈尔滨医科大学附属第一医院神经外科
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Pyroptosis;
Inflammasome;
NLR family,pyrin domain-containing 3 protein;
Neuroinflammation;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2025;22(5):349-355
- CountryChina
- Language:Chinese
-
Abstract:
Subarachnoid hemorrhage(SAH)is a major subtype of stroke,characterized by high mortality and disability rates.Pyroptosis,a form of programmed cell death,has been identified as a key pathological process in early brain injury.Current research indicates that pyroptosis can occur in neurons,microglia,astrocytes,and cerebral vascular endothelial cells after SAH,leading to neurological dysfunction,brain edema,and disruption of the blood-brain barrier.The NOD-like receptor protein 3(NLRP3)inflammasome is regarded as a central regulatory component of pyroptosis,and its activation mechanisms and roles in various cell types have become focal points of research.A variety of therapeutic strategies targeting this pathway have emerged,including NLRP3 inhibitors,Caspase-1 inhibitors,and Gasdermin-D inhibitors.The aforemenetioned approaches all have demonstrated efficacy in animal studies.Additionally,novel technologies such as stem cell therapy,exosome therapy,and gas therapy offer novel intervention approaches for modulating pyroptosis.Although,various therapeutic strategies targeting pyroptosis-related pathways have emerged in recent years,a comprehensive summary remains absent.This article reviewed the advancements in pyroptosis research following SAH and associated treatment strategies,aiming to provide a theoretical foundation for subsequent mechanistic studies and clinical translation.
