Role of gut microbiota in systemic inflammation and treatment of cachexia
10.3969/j.issn.1000-484X.2025.06.042
- VernacularTitle:肠道菌群在恶病质全身性炎症及治疗的作用
- Author:
Tao WU
1
;
Yiwei QU
;
Yong WANG
;
Xiao LI
;
Dufang MA
Author Information
1. 山东中医药大学第一临床医学院,济南 250013
- Publication Type:Journal Article
- Keywords:
Cachexia;
Gut microbiota;
Systemic inflammation
- From:
Chinese Journal of Immunology
2025;41(6):1517-1522
- CountryChina
- Language:Chinese
-
Abstract:
Systemic inflammation of cachexia is an important cause of high mortality of degenerative diseases such as ad-vanced cancer,and also the most important factor to aggravate the cachexia process.Systemic inflammation of cachexia has a profound impact on the proliferation and invasion of tumors and the catabolism of muscle and adipose tissue in patients with cachexia.In recent years,studies have shown that the dysfunction of gut microbiota during cachexia is an important cause of cachexia systemic inflamma-tion and a key therapeutic target.The dysfunctions of intestinal barrier mediated by gut microbiota and the translocation of bacterial tox-ins during the cachexia period are important causes of cachexia systemic inflammation.This article mainly summarized the relationship between gut microbiota and cachexia systemic inflammation,and summarized the mechanism of intestinal flora inducing cachexia sys-temic inflammation by regulating short chain fatty acids,lipopolysaccharide,flagellin,peptidoglycan and other substances,with a view to providing new ideas for the prevention and treatment of cachexia systemic inflammation from the perspective of intestinal flora.
