Focusing on sense of urgency and entry point of innate and adaptive immunity in study of ankylosing spondylitis mechanisms
10.3969/j.issn.1000-484X.2025.06.039
- VernacularTitle:聚焦固有和适应性免疫在强直性脊柱炎机制研究中的紧迫感与切入点
- Author:
Yuening CHEN
1
;
Hongxiao LIU
1
Author Information
1. 中国中医科学院广安门医院风湿病科,北京 100051
- Publication Type:Journal Article
- Keywords:
Ankylosing spondylitis;
Innate immunity;
Adaptive immunity
- From:
Chinese Journal of Immunology
2025;41(6):1497-1503
- CountryChina
- Language:Chinese
-
Abstract:
Ankylosing spondylitis(AS)is a worldwide refractory autoimmune disease whose exact etiology is not fully under-stood,and disorders of body's immune system are currently thought to play an important driving role in development of AS.Previous studies generally attach great importance to role of T cells in pathogenesis of AS.With in-depth research on AS,more and more evidence indicates that both innate immune cells and adaptive immune cells can trigger AS and are closely related to three core patho-logical links of AS,namely inflammation,bone destruction and new bone formation.In this article,we discuss mechanisms involved in development of AS by both innate and adaptive immune cells,with aim of providing new ideas for treatment of AS.
