Treatment strategies for limited-stage primary small cell carcinoma of esophagus
10.3969/j.issn.1006-5725.2025.11.001
- VernacularTitle:局限期原发性食管小细胞癌的治疗策略
- Author:
Xiaolin QIU
1
;
Bingjie FAN
;
Linlin WANG
Author Information
1. 山东第二医科大学临床医学院(山东潍坊 261053);山东省肿瘤防治研究院(山东省肿瘤医院)放疗科,山东第一医科大学(山东省医学科学院)(山东济南 250117)
- Publication Type:Journal Article
- Keywords:
small cell carcinoma;
esophageal carcinoma;
treatment;
survival
- From:
The Journal of Practical Medicine
2025;41(11):1603-1610
- CountryChina
- Language:Chinese
-
Abstract:
Primary small cell carcinoma of esophagus(PSCCE)is a rare and highly aggressive neuroendocrine tumor,accounting for 0.05%to 3.1%of all esophageal malignancies.Its biological characteristics are similar to those of small cell lung cancer,with highly aggressive behavior and early dissemination tendency.It often metasta-sizes rapidly through lymphatic and hematogenous pathways.The prognosis is extremely poor,with a 5-year overall survival rate of less than 15%.There are no large-scale randomized controlled trials,and no standard treatment strategies have been established.In recent years,the treatment of limited-stage PSCCE has become a focal point of research.In traditional treatment paradigms,endoscopic therapy is feasible for very early-stage cases,while radical surgery serves as the primary approach for relatively early-stage patients.For locally advanced cases,two predominant treatment modalities are commonly employed in clinical practice:a surgery-based comprehensive treatment regimen and a radical chemoradiotherapy-centered therapeutic protocol,with no definitive conclusion yet reached regarding the optimal treatment strategy.Concurrently,emerging therapeutic strategies such as immuno-therapy and molecularly targeted therapy have demonstrated remarkable clinical efficacy,thereby providing novel therapeutic opportunities for limited-stage PSCCE.This article aims to review the recent advances in the treatment of limited-stage PSCCE,summarize the current diagnostic and therapeutic landscape,and outline future directions in this field.
