The Research Progress of Second Cancer Onset in Myeloprolifera-tive Neoplasms——Review
10.19746/j.cnki.issn1009-2137.2025.06.043
- VernacularTitle:骨髓增殖性肿瘤患者继发第二肿瘤的研究进展
- Author:
Jing-Yun ZOU
1
;
Shi-Xuan WANG
1
;
Fei LI
1
Author Information
1. 南昌大学江西医学院,南昌大学第一附属医院血液病中心,江西省血液病临床医学研究中心,江西南昌 330006
- Publication Type:Journal Article
- Keywords:
myeloproliferative neoplasm;
second cancer;
pathogenesis
- From:
Journal of Experimental Hematology
2025;33(6):1825-1828
- CountryChina
- Language:Chinese
-
Abstract:
Patients with myeloproliferative neoplasms(MPNs)are at risk of developing solid tumors.Although the connection between MPN and solid tumors has been widely discussed,the cause remains to be explored.Some studies show that the MPN is considered to trigger a second cancer,but others suggest both diseases seem to share the same origin.In recent years,more and more studies have found that genetic susceptibility,drugs,chronic inflammation,immune function abnormalities and clonal hematopoiesis of indeterminate potential are related to the development of second cancers.In this review,we try to summarize the new advances of biological characteristics and pathogenesis of second cancers in MPNs.
