Risk factors and model analysis of poor prognosis in patients with systemic lupus erythematosus with reduced complement C3 level
10.3969/j.issn.1000-484X.2025.06.035
- VernacularTitle:系统性红斑狼疮伴补体C3水平降低患者预后不良的危险因素及模型分析
- Author:
Wuwei ZHOU
1
;
Xianli HE
1
;
Ansheng NONG
1
;
Weixiang ZHU
1
Author Information
1. 崇左市人民医院肾内风湿免疫科,崇左 532200
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
Complement C3;
Prognosis;
Risk factors
- From:
Chinese Journal of Immunology
2025;41(6):1473-1477
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore prognosis and related risk factors of patients with systemic lupus erythematosus(SLE)combined with decreased complement C3 level.Methods:A total of 173 SLE patients with decreased complement C3 level who were treated in Chongzuo People's Hospital from June 2018 to March 2022 were selected as research subjects,and divided into good progno-sis group(n=151)and poor prognosis group(n=22)according to follow-up prognostic effect.Clinical data and biochemical indicators of patients were recorded.A nomogram model was established for analysis and model validation.Results:There were statistical signifi-cance in lupus activity,C3,A/G,hs-CRP between two groups(P<0.05);lupus activity,C3,A/G,hs-CRP were independent risk factors for outcomes of SLE patients with reduced complement C3.Prediction effect of nomogram model was good,and consistency of model validation was strong.Complement C3 level was correlated with SLE(χ2=7.524,P=0.002),with a linear dose-response relation-ship(χ2=1.527,P=0.118).Conclusion:SLE patients with decreased complement C3 level have poor prognosis,who has many risk factor.Prognosis of SLE can be enhanced from aspects of lupus activity,C3,A/G and hs-CRP.
