18F-FDG PET/CT metabolic parameters for differentiating benign and malignant nodular thickening around staple line after resection of non-small cell lung cancer
10.13929/j.issn.1003-3289.2025.05.010
- VernacularTitle:18F-FDG PET/CT代谢参数鉴别非小细胞肺癌术后良、恶性线缘结节状增厚
- Author:
Min FAN
1
;
Lei MA
;
Xun SHI
Author Information
1. 南京大学医学院附属盐城第一医院(盐城市第一人民医院)核医学科,江苏盐城 224000
- Publication Type:Journal Article
- Keywords:
carcinoma,non-small-cell lung;
recurrence;
fluorodeoxyglucose F18;
positron emission tomography computed tomography
- From:
Chinese Journal of Medical Imaging Technology
2025;41(5):744-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of 18F-FDG PET/CT metabolic parameters for differentiating benign and malignant nodular thickening around the staple line after resection of non-small cell lung cancer(NSCLC).Methods Fifty NSCLC patients after surgical resection who underwent 18F-FDG PET/CT examination were retrospectively collected,with a total of 52 lesions of nodular thickening around the staple line,including 31 lesions of recurrent NSCLC in 31 patients(recurrent group)and 21 benign lesions in 19 patients(non-recurrent group).18F-FDG PET/CT metabolic parameters,including the maximum standard uptake value(SUVmax),metabolic tumor volume(MTV),total lesion glycolysis(TLG)and the ratio of lesion's SUVmax to mediastinal blood pool SUVmax(SUVmax-ratio)were compared between groups.Receiver operating characteristic(ROC)curves were drew for parameters being statistically different between groups,and the area under the curve(AUC)was used to evaluate their diagnostic performance for distinguishing benign and malignant nodular thickening around the staple line after resection of NSCLC.Results SUVmax,TLG and SUVmax-ratio of lesions in recurrent group were all higher than those in non-recurrent group(all P＜0.05),while no significant difference of lesions' MTV was found between groups(P＞0.05).The AUC of SUVmax,TLG and SUVmax-ratio for differentiating malignant and benign nodular thickening around the staple line after resection of NSCLC was 0.854,0.805 and 0.887,respectively,all were not statistically different(all P＞0.05).Conclusion 18 F-FDG PET/CT metabolic parameters could be used to effectively differentiate malignant and benign nodular thickening around the staple line after resection of NSCLC.
