Left atrial volumetric/mechanical coupling index for predicting left atrial dysfunction in patients with chronic kidney disease
10.13929/j.issn.1003-3289.2025.05.008
- VernacularTitle:左心房容积/机械耦合指数预测慢性肾脏病患者左心房功能受损
- Author:
Liqin JI
1
;
Weiwei XIAO
;
Xue GAO
;
Houyu LI
;
Anlingzi ZOU
;
Xinru ZHANG
;
Zhuomeng MIAO
;
Shaomei YU
Author Information
1. 贵州医科大学附属医院超声医学科,贵州贵阳 550004;贵州医科大学医学影像学院,贵州 贵阳 550004
- Publication Type:Journal Article
- Keywords:
nephrosis;
echocardiography;
atrial function,left
- From:
Chinese Journal of Medical Imaging Technology
2025;41(5):733-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of left atrial volume/mechanical coupling index(LACI)for predicting left atrial(LA)dysfunction in patients with chronic kidney disease(CKD).Methods Totally 213 CKD patients(CKD group)and 50 healthy controls(control group)were enrolled.Clinical data,laboratory indicators and echocardiographic parameters were compared between groups.According to quartile values of LACI,patients in CKD group were further divided into 4 subgroups,and their clinical,laboratory indicators and echocardiographic parameters were compared.The correlations between LACI and laboratory markers of myocardial injury as well as echocardiographic parameters were analyzed.Taken LAVI＞34 ml/m2 as LA dysfunction,the efficacy of LACI,LA strain and LA stiffness index(LASI)for predicting LA dysfunction in CKD patients were evaluated.Results Statistical differences of gender,blood pressure,creatinine,estimated glomerular filtration rate(eGFR),cardia troponinT(cTnT),creatine kinase isoenzymes(CK-MB)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)were found between groups(all P＜0.05).In CKD group,with the increase of LACI,the prevalence of blood pressure and diabetes,the levels of cTnT and NT-proBNP in different subgroups showed increasing trend,while eGFR showed a decreasing trend.LACI was correlated with cTnT,CK-MB,NT-proBNP and multiple echocardiographic parameters(all P＜0.001).The AUC of LACI for predicting LA dysfunction in CKD patients was 0.884,higher than that of LA strain during reservoir phase,conduit phase,contraction phase and LASI(AUC=0.652,0.621,0.611,0.746,all P＜0.05).Conclusion LACI could be used to effectively predict LA dysfunction in CKD patients.
