Research progress of Rho GTPase activating protein for regulator of tumor cell migration
10.3969/j.issn.1006-5725.2025.11.021
- VernacularTitle:肿瘤细胞迁移关键调节因子Rho GTPase激活蛋白研究进展
- Author:
Shihan CHEN
1
;
Yong JI
;
Wei ZHU
Author Information
1. 江苏大学医学院检验系(江苏镇江 212013)
- Publication Type:Journal Article
- Keywords:
ARHGAP;
Rho GTPase;
tumor;
migration;
signaling pathway
- From:
The Journal of Practical Medicine
2025;41(11):1751-1759
- CountryChina
- Language:Chinese
-
Abstract:
Rho GTPase-activating proteins(ARHGAP)constitute a family of multifunctional regulatory proteins that negatively regulate Rho family GTPases(e.g.,RhoA,Rac1,Cdc42)by accelerating the hydrolysis bound to these enzymes.Members of this family are extensively involved in crucial biological processes such as cellular signal transduction,adhesion,and dynamic reorganization of cytoskeleton,while also playing significant roles in tumor progression.ARHGAP expression and function vary across cancer types,with identical molecule exhibiting divergent expression levels and biological effects in various malignancies.The regulatory effects of ARH-GAP family members on tumor cell migration are closely associated with their unique structural domain characteris-tics and are modulated by multiple signaling pathways.This paper comprehensively analyzes and summarizes exist-ing research to explore the roles and mechanisms of ARHGAP family members in tumor cell migration,aiming to identify potential biomarkers and therapeutic targets in cancer management and prevention.
