Active monitoring of ceftazidime-avibactam sodium-related adverse reactions of blood system and influencing factors
10.11816/cn.ni.2025-242095
- VernacularTitle:头孢他啶阿维巴坦钠相关血液系统不良反应主动监测及影响因素分析
- Author:
Ru WANG
1
;
Mengqian QIAO
1
;
Wanyue CHENG
1
;
Man ZHU
1
;
Hong YIN
1
Author Information
1. 解放军总医院医疗保障中心药剂科,北京 100853
- Publication Type:Journal Article
- Keywords:
Ceftazidime-avibactam sodium;
Blood system;
Active monitoring;
Drug adverse reaction;
Real-world research
- From:
Chinese Journal of Nosocomiology
2025;35(10):1557-1562
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To acquire the real-world incidence of ceftazidime-avibactam sodium(CAZ)-related ad-verse reactions of blood system among a large sample of drug medication patients based on the active monitoring system so as to provide reference for safe clinical use of drugs.METHOD With the help of'Adverse Drug Event Active Surveillance and Assessment System-Ⅱ'(ADE-ASAS-Ⅱ),the use of CAZ of the patients who were hospi-talized in Chinese PLA General Hospital from Jan.1,2020 to Dec.31,2023 were retrospectively and automatical-ly monitored,the patients who were alarmed by system were evaluated by two persons,the incidence rates of CAZ-related thrombocytopenia,hemoglobin decreased and leucopenia were calculated,and the related influencing factors were analyzed.RESULTS Among the 278 case-times(191 cases)of patients who were treated with drugs and were enrolled in the study,there were 3(1.08％)case-times of thrombocytopenia,8(2.88％)case-times of hemoglobin decreased and 19(6.83％)case-times of leucopenia;the total incidence of adverse reactions of blood system was 10.79％.Logistic regression analysis showed that age and duration of drug administration were the in-fluencing factors for the CAZ-related adverse reactions of blood system.CONCLUSIONS It is common for the CAZ-related adverse reactions of blood system.The middle-aged and elderly patients who take drug therapy for a long time period are more likely to have the blood system-related adverse reactions.It is necessary to focus on the monitoring of renal function of the patients and adjust the dosage of administration in a timely manner so as to re-duce the incidence of adverse reactions of the blood system.
