Influence of human cytomegalovirus infection on TGF-β/Smad signaling pathways and Th1/Th2 cytokines of patients with diabetic retinopathy
10.11816/cn.ni.2025-240956
- VernacularTitle:人巨细胞病毒感染对糖尿病视网膜病变患者TGF-β/Smad信号通路及Th1/Th2型细胞因子的影响
- Author:
Lei MAO
1
;
Mingsheng HU
1
;
Wei LIU
1
;
Siyuan NIE
1
Author Information
1. 新余市人民医院眼科,江西新余 338000
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Human cytomegalovirus;
Transforming growth factor β/Smad signaling path-way;
Helper T cell 1;
Helper T cell 2
- From:
Chinese Journal of Nosocomiology
2025;35(9):1342-1346
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the influence of human cytomegalovirus(HCMV)infection on transforming growth factor β(TGF-β)/Smad signaling pathway and helper T cell(Th)1/Th2 cytokines of the patients with di-abetic retinopathy(DR)so as to provide guidance for clinical treatment of the DR patients with HCMV infection.METHODS Totally 100 DR patients complicated with HCMV infection who were treated in Xinyu People's Hospi-tal from Jan.2021 to Dec.2023 were assigned as the HCMV infection group and were divided into the non-prolif-erative DR group(NPDR group)and the proliferative DR group(the PDR group)according to the degree of path-ological change of retina.Meanwhile,100 DR patients without HCMV infection were chosen as the no HCMV in-fection group.The levels of serum TGF-β,interferon-γ(IFN-γ)and interleukin(IL)-4 as well as the relative ex-pression levels of Smad2 and Smad3 mRNA were observed.RESULTS The levels of serum TGF-β,IFN-γ and IL-4 of the HCMV infection group were respectively 1.41±0.43,(92.68±15.86)ng/L and(593.91±84.67)ng/L,higher than those of the no HCMV infection group;the relative expression levels of Smad2 mRNA and Smad3 mRNA of the HCMV infection group were respectively(1.54±0.44)and(1.68±0.50),higher than those of the no HCMV infection group(P＜0.05);the levels of the above indexes of the PDR group were higher than those of the NPDR group(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)of the joint detection of TGF-β,IFN-γ,IL-4,Smad2 and Smad3 was 0.961 in prediction of HC-MV infection in the DR patients,with the sensitivity 90.70％,the specificity 85.10％.CONCLUSION The HC-MV infection may aggravate the degree of retinopathy,which may be associated with the regulation of TGF-β/Smad signaling pathways and imbalance of Th1/Th2 function.
