Detection of Triple-Negative Breast Cancer Using Conventional Ultrasound Combining with Ultrasound Radiomics
10.3969/j.issn.1005-5185.2025.05.015
- VernacularTitle:常规超声联合超声影像组学检出三阴性乳腺癌的价值
- Author:
ZUMURETI·TUERHONG
1
;
Jinhui LIU
;
Lin QIU
;
Yuexin MA
;
Xiaoling LENG
Author Information
1. 新疆医科大学附属肿瘤医院超声科,新疆 乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Ultrasonography;
Radiomics;
Molecular typing;
Nomogram
- From:
Chinese Journal of Medical Imaging
2025;33(5):537-543
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the value of conventional ultrasound combined with ultrasound radiomics in detecting triple-negative breast cancer(TNBC).Materials and Methods In this study,we retrospectively collected the preoperative conventional ultrasound images and clinic-pathological data of 682 patients with lumpy breast cancer from the Affiliated Cancer Hospital of Xinjiang Medical University from January 2015 to December 2021.All patients included 325 cases with TNBC and 357 cases with non-TNBC.Features were extracted from preoperative ultrasound images of patients,screened,dimensionally reduced,and a combined model was constructed with ultrasound features and clinicopathological features.The performance of the three single models and combined models was evaluated by receiver operating characteristic curve analysis.Results The area under the curve of conventional ultrasound model,clinicopathological model,ultrasound imaging omics and the combined model in training group and validation suite were 0.730,0.718,0.982,0.985,0.726,0.683,0.981 and 0.982,respectively.The area under the curve of TNBC detected by the combined model was significantly higher than that of the single model(Z=7.311,7.024,3.883,all P<0.01).Conclusion The combined model based on ultrasonography has good diagnostic efficacy in detecting TNBC.As a non-invasive examination,it can avoid unnecessary biopsy to the patient.
