Distribution of pathogens,CD36,mTORC1,sCD14-ST and HDC of hilar cholangiocarcinoma patients with biliary tract infections after ERCP
10.11816/cn.ni.2025-241257
- VernacularTitle:肝门部胆管癌患者ERCP术后胆道感染病原菌分布及CD36、mTORC1、sCD14-ST、HDC水平
- Author:
Lili LENG
1
;
Min CHEN
;
Zhengfei WANG
Author Information
1. 浙大邵逸夫医院龙游分院肝病感染科,浙江衢州 324400
- Publication Type:Journal Article
- Keywords:
Hilar cholangiocarcinoma;
Endoscopic retrograde cholangiography and pancreatography;
Biliary tract infection;
Inflammatory factor;
Pathogen;
CD36/mammalian target of rapamycin complex 1;
Soluble CD14 sub-type;
Histidine decarboxylase
- From:
Chinese Journal of Nosocomiology
2025;35(9):1352-1356
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the distribution of pathogens and the levels of CD36/mammalian target of rapa-mycin complex 1(mTORC1),soluble CD14 subtype(sCD14-ST)and histidine decarboxylase(HDC)in the hilar cholangiocarcinoma(HC)patients who had biliary tract infection after endoscopic retrograde cholangiography and pancreatography(ERCP).METHODS Totally 106 HC patients who were treated in Zhejiang University Sir Run Run Shaw Hospital Longyou Branch from Feb.2021 to Feb.2024 were enrolled in the study and were divided into the infection group with 31 cases and the non-infection group with 75 cases according to the status of biliary tract infection after ERCP.The distribution of pathogens causing the postoperative infections was statistically analyzed,the inflammatory factors were detected,the levels of CD36,mTORC1,sCD14-ST and HDC were observed and compared between the two groups of patients,and their values in diagnosis of postoperative biliary tract infections were analyzed.RESULTS Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii and Enterococcus faecalis were the major species of pathogens that were isolated from the HC patients with biliary tract infections after ERCP.There were significant differences in the levels of interleukin(IL)-6,IL-1β,procalcitonin(PCT)and C-reactive protein(CRP)between the infection group and the non-infection group(P＜0.05);the levels of above indexes of the infection group were(39.56±6.64)ng/L,(196.72±26.51)pg/ml,(8.89±1.37)ng/ml and(17.93±3.52)mg/L,respectively,higher than those of the non-infection group.The levels of CD36,mTORC1,sCD14-ST and HDC of the infection group were 4.02±1.32,1.98±0.66,(41.79±13.68)ng/ml and(33.57±11.12)ng/ml,respectively,higher than those of the non-infection group(P＜0.05).The area under the curve(AUC)of the joint detection of the four indexes was 0.949 in diagnosis of the biliary tract infections in the HC pa-tients after ERCP,with the sensitivity 90.32％,the specificity 86.67％.CONCLUSION E.coli,K.pneumoniae,A.baumannii and E.faecalis are the major species of pathogens isolated from the HC patients with biliary tract infections after ERCP.The infections may lead to the activation of CD36/mTORC1 pathways and the high expres-sions of inflammatory factors,sCD14-ST and HDC.The joint detection of CD36,mTORC1,sCD14-ST and HDC has high value in diagnosis of the biliary tract infections in the HC patients after ERCP.
