Preoperative Prediction of Tumour Mutation Burden in Hepatocellular Carcinoma Based on CT-Enhanced Examination
10.3969/j.issn.1005-5185.2025.06.016
- VernacularTitle:基于增强CT术前预测肝细胞癌肿瘤突变负荷的临床价值
- Author:
Yiman LI
1
;
Jie CHENG
;
Fengxi CHEN
;
Ping CAI
;
Yang LAN
;
Xiaoming LI
Author Information
1. 陆军军医大学(第三军医大学)第一附属医院放射科,7T磁共振转化医学中心,重庆 400038
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Tumor mutation burden;
Tomography,X-ray computed;
Forecasting
- From:
Chinese Journal of Medical Imaging
2025;33(6):657-662
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the predictive value of CT-enhanced for tumor mutation burden(TMB)in hepatocellular carcinoma(HCC).Materials and Methods A total of 22 patients with pathologically confirmed HCC after undergoing radical resection in the First Affiliated Hospital,Army Medical University(Third Military Medical University)from January 2020 to January 2023 were collected,all of whom were quantified for TMB.Clinical,laboratory tests,CT imaging characteristics and follow-up of patients were recorded.Variables with P<0.2 were screened by stepwise regression analysis for independent risk factors for TMB.The area under the curve of receiver operating characteristic was used to assess the diagnostic efficacy.Results High TMB level was a risk factor for disease-free survival after HCC surgery(HR=1.115,P<0.05).According to the optimal cut-off value,TMB was classified into a high-risk group(>9.25 mutation/Mb)and low-risk group(≤9.25 mutation/Mb).Univariate analysis of intratumor ischemia or necrosis was statistically different between the high-risk and low-risk groups(P=0.005),and only intratumor ischemia or necrosis was an independent risk factor for predicting high TMB level by stepwise regression analysis(P<0.05).The area under the curve for predicting disease-free survival was 0.833(95%CI 0.615-0.956,P<0.001),with a sensitivity of 100.0%and a specificity of 66.7%.Conclusion High TMB level is associated with poor prognosis after HCC resection.Intratumor ischemia or necrosis have certain clinical value in predicting high TMB level,and are expected to provide a reference basis for personalized diagnosis and treatment of HCC patients.
