Clinical effects of Modified Fumai Decoction on patients with lower extremity arteriosclerosis obliterans due to Yin Deficiency and Blood Stasis
10.3969/j.issn.1001-1528.2025.06.012
- VernacularTitle:加减复脉汤对阴虚血瘀型下肢动脉硬化性闭塞症患者的临床疗效
- Author:
Yu WEI
1
;
Yi-lin GUO
1
Author Information
1. 泸州市中医医院普外三科,四川泸州 646000
- Publication Type:Journal Article
- Keywords:
Fumai Decoction;
Alprostadil Injection;
lower extremity arteriosclerosis obliterans;
Yin Deficiency and Blood Stasis;
coagulation functions;
thrombelastogram
- From:
Chinese Traditional Patent Medicine
2025;47(6):1861-1865
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Modified Fumai Decoction on patients with lower extremity arteriosclerosis obliterans due to Yin Deficiency and Blood Stasis.METHODS One hundred and fifty-two patients were randomly assigned into control group(76 cases)for 8-week administration of Alprostadil Injection,and observation group(76 cases)for 8-week administration of both Modified Fumai Decoction and Alprostadil Injection.The changes in clinical effects,TCM syndrome scores,coagulation function indices(PT,APTT,TT,FIB),thrombelastogram parameters(R,K,MA,αangle),vascular inflammatory factors(hs-CRP,TNF-α,IL-6,IL-1β),vascular endothelial function(VEGF,ET-1,NT-proBNP,NO)and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,FIB,vascular inflammatory factors,MA,αangle,ET-1,NT-proBNP(P＜0.05),prolonged PT,APTT,TT(P＜0.05),and increased R,K,VEGF,NO(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with lower extremity arteriosclerosis obliterans due to Yin Deficiency and Blood Stasis,Modified Fumai Decoction can safely and effectively regulate coagulation functions,and improve vascular endothelial functions.
