Preparation and properties of degradable and high-porosity sodium alginate/organic composite calcium salt porous scaffolds for tissue engineering
10.3969/j.issn.1005-202X.2025.11.017
- VernacularTitle:可降解高孔隙率海藻酸钠/有机复合钙盐组织工程多孔支架的制备与性能研究
- Author:
Weijing SUN
1
;
Yutong WU
;
Mingjun OU
;
Hanliu GU
;
Xiaoling ZUO
;
Xiaoying LIU
;
Yong YANG
;
Li WANG
Author Information
1. 成都医学院大健康与智能工程学院,四川 成都 610500
- Publication Type:Journal Article
- Keywords:
bone tissue engineering;
sodium alginate;
calcium citrate double salt;
freeze-drying;
porous scaffold
- From:
Chinese Journal of Medical Physics
2025;42(11):1514-1522
- CountryChina
- Language:Chinese
-
Abstract:
A porous composite scaffold is prepared through freeze-drying method using sodium alginate as the matrix and calcium citrate double salt as the functional enhancer.To thoroughly investigate the structure and properties of the composite scaffold,advanced instruments including Fourier transform infrared spectrometer,X-ray diffractometer,scanning electron microscope,and thermogravimetric analyzer are utilized for comprehensive structural characterization.Meanwhile,key properties such as porosity,mechanical performance,swelling ratio,gel fraction,and in vitro degradation rate are systematically tested and analyzed.The results show that the composite of sodium alginate and calcium citrate double salt is a physical complex.The porosity of the scaffold mainly ranges from 200 to 600 μm,and as the addition of double salt increases,the pore size firstly increases and then slightly decreases,while the pore distribution become more uneven.In terms of mechanical properties,with the gradual increase of the content of double salt in the scaffold,the mechanical properties of the scaffold are significantly improved.However,its swelling ratio and gel fraction exhibit decreasing trends.Additionally,the degradation rate of the alginate scaffold is relatively fast,while the addition of calcium citrate double salt does not significantly improve the degradation rate.This study not only provides valuable insights into the preparation and property research of porous composite scaffold composed of sodium alginate/calcium citrate double salt,but also offers important reference for their potential applications in biomedicine.
