Detection of liver ischemia sample signals using terahertz time-domain spectroscopy
10.3969/j.issn.1005-202X.2025.11.013
- VernacularTitle:基于太赫兹时域光谱技术检测肝脏缺血样本信号
- Author:
Yiwei GUAN
1
;
Shaohui GENG
;
Zixuan SHU
;
Han SHENG
;
Huawei WANG
;
Guangrui HUANG
Author Information
1. 北京中医药大学中药学院,北京 102488
- Publication Type:Journal Article
- Keywords:
liver ischemia;
terahertz time-domain spectroscopy;
organ damage;
principal component analysis
- From:
Chinese Journal of Medical Physics
2025;42(11):1488-1493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences in terahertz(THz)signal characteristics between normal and ischemic liver tissues of New Zealand rabbits using THz time-domain spectroscopy(THz-TDS),thereby providing a novel detection technique for the pathological detection of liver tissues.Methods Liver ischemia models were established in New Zealand rabbits.The THz scanning signal maps of normal and ischemic liver tissues were obtained using a reflective THz-TDS system,and the acquired signals were subjected to principal component analysis.Results Both normal and ischemic liver tissues displayed two distinct peaks in their THz signals.However,the amplitude of the THz signal in ischemic liver tissue was higher than that in normal liver tissue,with significant differences also observed in their signal morphologies.Principal component analysis results revealed a clear clustered distribution between the signals of normal and ischemic liver tissues,indicating that THz-TDS could effectively distinguish between the two tissue types.Conclusion THz-TDS can be applied to the detection of ischemic liver tissue,providing experimental evidence to support further research on the early diagnosis of liver ischemia and exhibiting broad prospects for clinical application.
