Association of hippocampal subfield volumes and cross-domain associative memory impairment in patients with schizophrenia
10.3969/j.issn.1672-8467.2025.06.001
- VernacularTitle:精神分裂症患者跨通道联想记忆缺陷与海马亚区体积改变的相关性
- Author:
Zhao-lin ZHAI
1
;
Di CHANG
;
Xuan LI
;
Chang LU
;
Yu-ke DONG
;
Yan WANG
;
Chun-hong SHAO
;
Qing KANG
;
Deng-tang LIU
Author Information
1. 复旦大学附属华山医院精神科 上海 200040;上海交通大学医学院附属精神卫生中心精神科 上海 200030;国家精神疾病医学中心-精神病性障碍临床诊疗中心 上海 200030
- Publication Type:Journal Article
- Keywords:
schizophrenia(SCZ);
associative memory(AM);
cross-domain;
hippocampus;
subfields segmentation
- From:
Fudan University Journal of Medical Sciences
2025;52(6):775-782
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible association between cross-domain associative memory(AM)impairment and hippocampal subfield volumes in patients with schizophrenia(SCZ).Methods We enrolled 28 SCZ patients from Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,and 28 healthy controls(HCs)between 2019 and 2021.Based on an innovative AM paradigm and automated segmentation,3D-T1 weighted data of the objects were processed with PhiPipe and FreeSurfer.Differences in subfield volums between the two groups were analyzed using ANCOVA,while their relationship with AM scores was assessed using Pearson correlation.Results SCZ patients exhibited significantly poorer AM performance across three conditions compared with HCs.Marginally significant reductions were observed in the total volume of bilateral hippocampus,encompassing both the hippocampal head and body.Significant volume reductions were identified in the bilateral presubiculum and parasubiculum.The volumes of bilateral presubiculum head(r=0.273,P=0.042),parasubiculum(r=0.397,P=0.002),and CA1 head(r=0.382,P=0.004)exhibited positive correlations with cross-domain AM performance.Conclusion The bilateral presubiculum and parasubiculum,as hippocampal subregions significantly associated with cross-modal AM deficits in SCZ,may play a crucial role in the pathology of AM.
