Clinical significance of serum bile acid profile in patients with early non-alcoholic fatty liver disease
10.3969/j.issn.1673-9701.2024.36.006
- VernacularTitle:血清胆汁酸谱在早期非酒精性脂肪性肝病患者中的临床意义
- Author:
Haoyue SUN
1
;
Mengjie XU
;
Lecan WU
;
Endian ZHENG
;
Yingcong YU
Author Information
1. 温州医科大学温州市第三临床学院 温州市人民医院 上海大学附属第三医院消化内科,浙江温州 325000
- Publication Type:Journal Article
- Keywords:
Early non-alcoholic fatty liver disease;
Taurocholic acid;
Taurochenodeoxycholic acid;
Serum bile acid profile
- From:
China Modern Doctor
2024;62(36):28-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum bile acid profiles in early non-alcoholic fatty liver disease(NAFLD)and explore their clinical significance at the same time combined with liver enzyme-related indicators.Methods A total of 58 patients with early NAFLD who were treated in Department of Gastroenterology,Wenzhou People's Hospital from January 2021 to December 2022 were selected as early NAFLD group,along with 66 healthy individuals as control group.Basic information and blood samples were collected and ultra performance liquid chromatography-mass spectrometry/mass spectrometry was used to determine 15 types of serum bile acid profile.Statistical analysis was performed in correlation with liver enzyme indicators.Results Compared with control group,serum concentration of taurocholic acid(TCA)and taurochenodeoxycholic acid(TCDCA)increased in early NAFLD group,which were highly correlated with the disease(VIP>1,p(corr)>0.6 according to SIMCA software analysis).Binary Logistic regression analysis showed that body mass index,total cholesterol,triglyceride,and TCA were independent risk factors in the early-stage of NAFLD,with OR(95%CI)values of 2.367(1.511-3.709),6.481(2.003-20.963),4.950(1.675-14.631)and 2.643(1.335-5.234)(TCA values were log2 transformed),with all P<0.05.Receiver operating characteristic curve analysis showed that TCA and TCDCA had a certain predictive capability in diagnosis of the early NAFLD,and the diagnostic evaluation ability was higher,and area under the curve of them were more than 0.7.Conclusion The bile acid profile of patients with early NAFLD are changed,mainly TCA and TCDCA,which have a positive correlation with the early NAFLD and expected to become a serological marker of early NAFLD.
